what does cálmate, Isabel.
what does calmate mean
Be calm. Relax.
You could also say "Tranquilo" meaning Take it easy"
or... if you were on the mean backstreets of Barcelona
"Tranqui, tranqui tio, que no te flipas" .. which, translated, is:
Easy, take it easy dude, don't flip out. Cue junky gestures