En que puedo ayudarle is the most normal everyday way to say that. En que puedo...in what....puedo ayudarle.....can I help you. This is a style thing and I came up in one way and others came up in another way. That's only what I'd say to you. Others would say it in another way. To a conocido, I would say, Que hay? In a professional setting, I would say En que puedo ayudarle?
Can he/she/it help you? More likely would be "¿Puedo ayudarle?
Shere, yes please, we can use all the help we can get