1. (informal) (general)
a. you're crazy
No puedes negar que estás loca por él.You can't deny that you're crazy about him.
Estás loca si crees que yo voy a saltar de ese puente.You're insane if you think I'll jump off that bridge.
c. you're mad
Estás loca, Marcela. Ni de broma te voy a ayudar a hacer eso.You're mad, Marcela. There's no way I'll help you do that.
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