What Does "ay, Dios mío" Mean in English?

Quick Answer

ay, Dios mío  = Oh my God, oh my gosh, oh my goodness, Jesus, or jeez

¡Ay, Dios mío! Se acaban de chocar dos tráilers.
Oh my God! Two semis just crashed into each other.
Se me olvidó pagar la renta. - Ay, Dios mío. ¿Otra vez?
I forgot to pay the rent. - Jeez. Again?
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