How do you say: What does __ mean? in spanish
What does __ mean?
Without any additional context, the blank should be filled with a word in (say, English) when you want to know what it means in English). The reasonable answer to "What does X mean in Spanish (if X is a word/phrase in English)? would be 'nothing' (because it's not Spanish).
If, on the other hand, you seek a translation, you would do better to ask "How does one say X in Spanish/English/etc.?" Or "What is the equivalent of X in Spanish?" Or "How does one translate X to Spanish?"