ASK A QUESTION ¿Qué significa "what is it?"?
que significa what is it
The title may be:
"Qué significa" What is it?
Without punctuation the question is totally ambiguous.
¿Qué es? o ¿Cuál es? depende en el contexto
Qué significa means "What does it mean?"
So if you don't understand a word, you can say "Qué significa la palabra ___?" or "What does ___ mean?"